20th International Congress on In Vitro Toxicology 2018, Berlin (D)

The aim of the conference which will take place on 15 - 18 October in Berlin (D) is to provide an opportunity to update attendees with the latest advances in the field of in vitro toxicology as well as facilitating networking with other delegates working in this area. Abstract submission will be opened in January 2018. For further information see conference website.

Cefic-LRI research grants - Submission deadline is 31 August 2017

The Long-range Research Initiative (LRI) programme of the European Chemical Industry Council (Cefic) is accepting research grant applications in areas including Toxicokinetics mammalian modelling (ECO44), Assessment of inhalation and dermal exposure in industrial/professional use (B20), Development of omics data analysis (C4), Understanding normal adaptation vs pathology and gene expression time dependence (C5), and Omics read-across (C6). Submission deadline is 31 August 2017. For further information see here.

Filling gaps in (eco)toxicity data by OECD QSAR toolbox

This toolbox is a software application intended for use by regulatory authorities, chemical industry and other stakeholders in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals. Version 4.0 was released in June 2017. New features:

  •  Automated and standardised workflows for skin sensitisation and short-term toxicity to fish,
  • Improved customisable reports,
  • Modernised and renewed IT system,
  • Expansion of databases and the introduction of the reliability score for alerts and databases,
  • Enhanced ADME (kinetics) information and improved presentation.

AOP online course now openly available

The Human Toxicology Project Consortium has developed an eLearning course on the AOP framework, its history and importance, and how to develop and submit quality AOPs to the AOP-Wiki. The course is openly available on this website. Other current AOP training activities are listed here.

Apply now for EFSA’s scientific panels

The European Food Safety Authority EFSA is looking for scientific experts for its ten Scientific Panels and its Scientific Committee, which are at the heart of EFSA’s mission to produce high-quality independent scientific advice for political decision-makers in Europe. Submit your application between 1 June and 8 September 2017. For further information click here.

ECHA releases key information on 15’000 chemicals

The European Chemicals Agency is making selected data on 15’000 chemicals available for download with the aim of increasing its use by researchers, regulatory authorities and businesses. The aim is to improve the safe use of chemicals, enable innovation and help avoid the unnecessary testing of chemicals on animals. Further information can be found on the ECHA website.

EFSA prototype Adverse Outcome Pathways (AOPs) for Parkinson’s disease and infant leukaemia related to pesticide exposure

The European Food Safety Authority (EFSA) Panel on Plant Protection Products and their Residues (PPR) were requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson’s disease and childhood leukaemia. The Panel proposes the use of the Adverse Outcome Pathway (AOP) conceptual framework, to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP-derived Integrated Approach for Testing and Assessment (IATA). See press release and publication.

Vernehmlassung der Änderungen der Chemikalienverordnung und der Biozidprodukteverordnung

Das Eidgenössische Departement des Innern EDI führt ein Vernehmlassungsverfahren zur Änderung der Chemikalienverordnung (ChemV; SR 813.11) und der Biozidprodukteverordnung (VBP; SR 813.12) durch. In der ChemV sollen Meldepflichten für chemische Zwischenprodukte, für synthetischen Nanomaterialien sowie für Firmen, die synthetische Nanomaterialien zur Herstellung von Produkten verwenden, eingeführt werden. Die Vernehmlassung läuft bis zum 15. Mai 2017. Weitere Informationen unter diesem Link.

Le Département fédéral de l'intérieur (DFI) mène une consultation relative à la modification de l'ordonnance sur les produits chimiques (OChim ; RS 813.11) et de l'ordonnance sur les produits biocides (OPBio ; RS 813.12). La révision de l'OChim prévoit de nouvelles obligations de communiquer applicables aux produits chimiques intermé-diaires et aux nanomatériaux synthétiques, ainsi qu'aux entreprises souhaitant utiliser de tels nanomatériaux pour fabriquer leurs produits. La consultation est ouverte jusqu'au 15 mai 2017. Des informations complémentaires sous ce lien.

CAAT Research Grants 2018 - 2019

CAAT’s research grants program is a centerpiece of its work, providing initial funding for scientists to develop alternatives to the use of animals in biomedical research and product safety testing. To date, the center has funded some 300 grants (including renewals) for a total of more than $6 million.

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report 'Toxicity Testing in the 21st Century: A Vision and a Strategy' in the following areas:

  • Proposals Relating to Toxicology: Maximum grant amount is $40,000 for up to 2 years. The objective should be to significantly reduce or replace laboratory animals. Projects should be developed to provide mechanistic understanding of in vitro responses to toxicants in human cells.  Consideration should be given to the translation of this new method to evaluate/predict health outcomes.
  • Proposal Relating to Refinement:  See Science-Based Animal Welfare Awards – funded separately.

Pre-proposal deadline: April 21, 2017. For further information see this link.

Verwendung von In vitro Tests zur Bestimmung der hautätzenden Wirkung von Chemikalien

Der Direktionsbereich Verbraucherschutz des Bundesamtes für Gesundheit (BAG) hat eine kurze Wegleitung, wie In vitro Tests zur Bestimmung der hautätzenden Wirkung von Chemikalien verwendet werden können, veröffentlicht. Weitere Informationen.

L'Unité de Direction Protection des Consommateurs de l'Office Fédéral de la Santé Publique (OFSP) a publié un guide abrégé indiquant comment classer, par le biais de tests in vitro, des produits chimiques pouvant provo-quer une corrosion cutanée. Des informations compémentaires.

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