Apply now for EFSA’s scientific panels

The European Food Safety Authority EFSA is looking for scientific experts for its ten Scientific Panels and its Scientific Committee, which are at the heart of EFSA’s mission to produce high-quality independent scientific advice for political decision-makers in Europe. Submit your application between 1 June and 8 September 2017. For further information click here.

ECHA releases key information on 15’000 chemicals

The European Chemicals Agency is making selected data on 15’000 chemicals available for download with the aim of increasing its use by researchers, regulatory authorities and businesses. The aim is to improve the safe use of chemicals, enable innovation and help avoid the unnecessary testing of chemicals on animals. Further information can be found on the ECHA website.

EFSA prototype Adverse Outcome Pathways (AOPs) for Parkinson’s disease and infant leukaemia related to pesticide exposure

The European Food Safety Authority (EFSA) Panel on Plant Protection Products and their Residues (PPR) were requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson’s disease and childhood leukaemia. The Panel proposes the use of the Adverse Outcome Pathway (AOP) conceptual framework, to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP-derived Integrated Approach for Testing and Assessment (IATA). See press release and publication.

Vernehmlassung der Änderungen der Chemikalienverordnung und der Biozidprodukteverordnung

Das Eidgenössische Departement des Innern EDI führt ein Vernehmlassungsverfahren zur Änderung der Chemikalienverordnung (ChemV; SR 813.11) und der Biozidprodukteverordnung (VBP; SR 813.12) durch. In der ChemV sollen Meldepflichten für chemische Zwischenprodukte, für synthetischen Nanomaterialien sowie für Firmen, die synthetische Nanomaterialien zur Herstellung von Produkten verwenden, eingeführt werden. Die Vernehmlassung läuft bis zum 15. Mai 2017. Weitere Informationen unter diesem Link.

Le Département fédéral de l'intérieur (DFI) mène une consultation relative à la modification de l'ordonnance sur les produits chimiques (OChim ; RS 813.11) et de l'ordonnance sur les produits biocides (OPBio ; RS 813.12). La révision de l'OChim prévoit de nouvelles obligations de communiquer applicables aux produits chimiques intermé-diaires et aux nanomatériaux synthétiques, ainsi qu'aux entreprises souhaitant utiliser de tels nanomatériaux pour fabriquer leurs produits. La consultation est ouverte jusqu'au 15 mai 2017. Des informations complémentaires sous ce lien.

CAAT Research Grants 2018 - 2019

CAAT’s research grants program is a centerpiece of its work, providing initial funding for scientists to develop alternatives to the use of animals in biomedical research and product safety testing. To date, the center has funded some 300 grants (including renewals) for a total of more than $6 million.

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report 'Toxicity Testing in the 21st Century: A Vision and a Strategy' in the following areas:

  • Proposals Relating to Toxicology: Maximum grant amount is $40,000 for up to 2 years. The objective should be to significantly reduce or replace laboratory animals. Projects should be developed to provide mechanistic understanding of in vitro responses to toxicants in human cells.  Consideration should be given to the translation of this new method to evaluate/predict health outcomes.
  • Proposal Relating to Refinement:  See Science-Based Animal Welfare Awards – funded separately.

Pre-proposal deadline: April 21, 2017. For further information see this link.

Verwendung von In vitro Tests zur Bestimmung der hautätzenden Wirkung von Chemikalien

Der Direktionsbereich Verbraucherschutz des Bundesamtes für Gesundheit (BAG) hat eine kurze Wegleitung, wie In vitro Tests zur Bestimmung der hautätzenden Wirkung von Chemikalien verwendet werden können, veröffentlicht. Weitere Informationen.

L'Unité de Direction Protection des Consommateurs de l'Office Fédéral de la Santé Publique (OFSP) a publié un guide abrégé indiquant comment classer, par le biais de tests in vitro, des produits chimiques pouvant provo-quer une corrosion cutanée. Des informations compémentaires.

LRI Innovative Science Award 2017: Apply now!

The Long-Range Research Initiative (LRI) of the European Chemical Industry Council (Cefic) together with SETAC, EUROTOX and ISES is offering a 100.000€ award to support promising new research in the field of dose-response of synergy in combined exposure to humans or environmental species.

The objective of this LRI Award is to stimulate innovative research, ‘out-of-the-box’ thinking and new approaches which will advance the development and application of new and existing approaches in the assessment of chemical safety. The research should be complementary to the Long-range Research Initiative’s (LRI) objectives, a chemical industry funded programme that aims at enhancing scientific knowledge to help protect health and the environment.

Deadline for applications: 19 March 2017. See further information.

OECD launches AOP Effectopedia version 1.0.

Effectopedia is an open-knowledge and structured platform able to display quantitative information on Adverse Outcome Pathways (AOPs). It is a collaborative tool designed to facilitate the interdisciplinary efforts for delineating AOPs in an encyclopedic manner with greater predictive power. For further information click here.

Glyphosat-Sicherheit: Stellungnahme des SCAHT/BLW

Am 9. Januar 2017 wurde eine wissenschaftliche Publikation (Mesnage et al 2017) mit dem Titel „Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide“ veröffentlicht. Das SCAHT hat in Zusammenarbeit mit dem BLW eine Stellungnahme zu dieser Publikation erarbeitet.

Die aktuelle Publikation (R. Mesnage et al 2017) schliesst an die“ Transcriptomics“ Publikation des gleichen Autors aus dem Jahr 2015 (R. Mesnage et al. 2015) an, in welcher der Einfluss von „ultra low“ dosiertem Roundup auf die Expressionsmuster von mRNA in Leber und Niere von Ratten untersucht wurde. Dies entspricht einer täglich verabreichten Glyphosatdosis von 4ng/kg Körpergewicht und liegt somit deutlich unter dem für Ratten abgeleiteten aktuellen chronischen NOAEL von 100 mg/kg Köpergewicht pro Tag der EFSA Conclusion für Glyphosat (European Food Safety Authority EFSA 2015). Beiden Studien vorausgegangen ist die Studie von Séralini aus dem Jahr 2012 (GE Séralini et al 2012, retracted 2013) in der u.a. die chronische Toxizität von Roundup an Ratten untersucht wurde (hier weiterlesen).

Weitere Informationen zum Glyphosat und dessen unterschiedliche Bewertung durch internationale Organisationen, die das SCAHT in Zusammenarbeit mit dem Oekotoxzentrum zusammengestellt hat, finden Sie unter diesem Link und eine entsprechende Kurzfassung in Deutsch und Französisch hier.

Season's Greetings

Dear friends and supporters of the SCAHT,
Just before the end of the year, we have received the great news of continued funding of our Centre through the Swiss Confederation. This success is the result of nearly two years of hard work by everyone involved. The core of our work over the next four years will be our strategic research programme. Together with regulatory toxicology and our educational efforts this is the basis for achieving our aim to build bridges between academic toxicological research and its application to regulatory decision making in the risk assessment and management of xenobiotics.
The positive development of the SCAHT would not have been possible without the active contribution of you and your colleagues. For this, we would once again like to express our sincere thanks.
We wish you and your families a peaceful and relaxing festive season and a very good start to the New Year 2017.

                          Martin Wilks and the SCAHT team

The SCAHT office will be closed from 23 December 2016 until 2 January 2017. We will be back in the office on 3 January 2017.

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