Publications by group

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Paech F
Messner S
Spickermann J
Wind M
Schmitt-Hoffmann AH
Witschi AT
Howell BA
Church RJ
Woodhead J
Engelhardt M
Maurer M
Archives of Toxicology

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines [Epub ahead of print]

Mingard C
Paech F
Journal of Applied Toxicology

The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

Grünig D
Felser A
Toxicology in Vitro

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Frontiers in Pharmacology

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

Archives of Toxicology

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler P
Joerin L
Toxicological Sciences

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

Haegler P
Grünig D
Berger B
PLoS One

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

Berger B
Donzelli M
Maseneni S
Boess F
Roth A
Haschke M
Frontiers in Pharmacology

Interactions between silica nanoparticles and phospholipid membranes

Kettiger H
Québatte G
Perrone B
Biochimica et Biophysica acta

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency

Haegler P
Singh F
Joerin L
Felser A
Duthaler U
Frontiers in Physiology

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

Witzigmann D
Schenk SH
Quintavalle C
Hepatology Research

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Bonifacio A
Mullen PJ
Mityko IS
Navegantes LC
Archives of Toxicology

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Singh F
Charles AL
Schlagowski AI
Bonifacio A
Echaniz-Laguna A
Geny B
Zoll J
Antioxidants & Redox Signaling

Comparative safety evaluation of silica-based particles

Kettiger H
Sen Karaman D
Schiesser L
Rosenholm JM
Toxicology In Vitro

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Marti P
Stein C
Blumer T
Abraham Y
Dill MT
Pikiolek M
Orsini V
Jurisic G
Megel P
Makowska Z
Agarinis C
Tornillo L
Bouwmeester T
Ruffner H
Bauer A
Parker CN
Schmelzle T
Heim MH
Tchorz JS

Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity


The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

Bonifacio A
Sanvee GM
Biochimica et Biophysica Acta

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

Singh F
Charles AL
Schlagowski AI
Bonifacio A
Piquard F
Geny B
Zoll J
Biochimica et Biophysica acta

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor

Seeland S
Murphy M
Treiber A
Giller J
Kiss A
Sube R
Hafner M
Pharmacology Research & Perspectives

Scientific Basis for Regulatory Decision-Making of Nanomaterials. Report on the Workshop, 20 – 21 January 2014, Center of Applied Ecotoxicology, Dübendorf

Studer C
Gasic B
von Goetz N
Hoet P
Kägi R
Kase R
Kobe A
Nowack B
Rothen-Rutishauser B
Schirmer K
Schneider G
Vermeissen E
Wick P
Walser T

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

Zhang L
Tang F
Hynx D
Kohler R
Bichet S
Hess D
Cron P
Hemmings BA
Hergovich A
Schmitz-Rohmer D
Current Biology

Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells

Chantong B
Lister A
Journal of Neuroinflammation

Evaluation of sparfloxacin distribution by mass spectrometry imaging in a phototoxicity model

Boudon SM
Morandi G
Prideaux B
Staab D
Junker U
Stoeckli M
Bauer D
Journal of the American Society for Mass Spectrometry

Dibutyltin promotes oxidative stress and increases inflammatorymediators in BV-2 microglia cells

Chantong B
Lister A
Toxicology Letters

Hepatocellular toxicity of benzbromarone: Effects on mitochondrial function and structure

Felser A
Lindinger PW
Schnell D
Mies S
Jenö P

Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice

Tao J
Calvisi DF
Ranganathan S
Cigliano A
Zhou L
Singh S
Jiang L
Fan B
Armeanu-Ebinger S
Ribback S
Dombrowski F
Evert M
Chen X
Monga SP

Hepatic toxicity of dronedarone in mice: Role of mitochondrial β-oxidation

Felser A
Stoller A
Morand R
Schnell D
Donzelli M

T Cells Infiltrate the Liver and Kill Hepatocytes in HLA-B(∗)57:01-Associated Floxacillin-Induced Liver Injury

Wuillemin N
Beltraminelli H
Schlapbach C
Fontana S
The American Journal of Pathology

Polymersomes containing quantum dots for cellular imaging

Camblin M
Detampel P
Wu D
Balasubramanian V
International Journal of Nanomedicine

Characterization of vemurafenib phototoxicity in a mouse model. Toxicological Sciences

Boudon SM
Plappert-Helbig U
Bauer D
Toxicological Sciences