Additional projects

SCAHT is also involved in other defined areas of research including the following collaborative projects:

​For details on the projects see descriptions below.


European Drug Emergency Network (Euro-DEN) collecting data on recreational drug use

Project Lead

  • Matthias Liechti, Universitätshospital Basel

Partners

  • P. Dargan, King’s College London (UK)
  • K. E. Hovda, Oslo University Hospital (N)
  • European Monitoring Centre for Drugs and Drug Addiction, Lisbon (P)
  • B. Megarbane, Lariboisière Hospital, Paris (F)
  • Other network members

Rationale for project

Hospital data show that every year thousands of individuals experience drug-related toxicity and other harm resulting in emergency department visits. The European Drug Emergencies Network (Euro-DEN) was set up to monitor drug-related emergency presentations across Europe. Basel acts as a Swiss centre in the project, which now includes 29 centres in 21 European countries.

Objectives

The goal of the project is to improve knowledge on acute drug toxicity relating to established illicit drugs as well as new psychoactive substances. The participating centres systematically collect toxicity data in emergency room admissions to identify, monitor and respond to new recreational drug use and adverse outcome patterns. The Basel research group also studies the pharmacology and toxicology of novel psychoactive substances in vitro.

For further information contact

Prof. Matthias Liechti
matthias.liechti@usb.ch


Exploring the impact of UV light on the oxidative capacity of airborne particles – a possible mechanism for the onset of metal fume fever?

Project description to follow.


Quantitative evaluation of the Key Events Relationships (KERs) resulting in impairment of learning and memory abilities (OECD AOP13) to support regulatory decision-making

Project description to follow.


New exposure biomarkers for glycol ethers in humans

Project Lead

  • Nancy Hopf, Institut universitaire romand de Santé au Travail (IST)

Partners

  • Myriam Borgatta, Institut universitaire romand de Santé au Travail (IST)
  • Stephan Krähenbühl, Universitätsspital Basel

Rationale for project

Millions of people are chronically exposed to glycol ethers through a wide range of household and professional products. Some glycol ethers are neurotoxic and reprotoxic leading to regulatory restrictions. The toxicity of ethylene glycol derivatives is mainly related to their metabolic transformation products, while metabolic transformation and toxicity of propylene glycol derivatives have not been extensively studied.

Objectives

There are three main objectives in the study: (1) Develop a chemical analytical method to analyse potential metabolites, (2) Determine hepatic metabolism and cytotoxicity in vitro, and (3) Quantify possible metabolites in urines from volunteers (n = 16) exposed to propylene glycol methyl ether (PGME, CAS no. 107-98-2) and the propylene glycol butyl ether (PGBE, CAS no 5131-66-8) under controlled conditions.

For further information contact

Dr. Nancy Hopf
nancy.hopf@hospvd.ch