13 Sep 2016 - 16 Sep 2016

SafeSciMET course "Innovative in vitro models of drug safety assessment", Liverpool (UK)

2D in vitro models to assess target organ toxicity potential of chemicals suffer from major limitations arising from lack of maintenance of physiological and chemical metabolism competence. 3D cell cultures have been receiving increasing attention as they permit the incorporation of 3D architecture, multiple cell types, flow and oxygen gradients, thereby better recapitulating an in vivo microenvironment. As these models have become more widely adopted, there has been corresponding improvements in high tissue-specific functionality, long-term viability, robustness, endpoint analysis, high-throughput screening and imaging analysis of these systems. This course will provide a review of different 3D microtissue and fluid-flow bioreactors used in toxicology and drug screening with a concise overview of the technologies, advantages and cost. Application examples of 3D cell-based systems to skin, heart and liver will be presented, in addition to a comparison of scaffold-free and scaffold-based methods. 
Organizer
European Modular Education and Training Programme in Safety Sciences for Medicines - SafeSciMET
Location
University of Liverpool Institute of Translational Medicine MRC Centre for Drug Safety Science Liverpool, UK
Link to Event
http://www.safescimet.eu/registration/docs/brochure/course_brochure_124.pdf