Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids

Jäger MC, González-Ruiz V, Joos FL, Winter DV, Boccard J, Degenhardt T, Brand S, Rudaz S, Thompson GR, Odermatt A

Frontiers in Pharmacology,  8 Aug 2024

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Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase [online ahead of print]

Jäger MC, Kędzierski J, Gell V, Wey T, Kollár J, Winter DV, Schuster D, Smieško M, Odermatt A

Toxicology and Applied Pharmacology,  15 Sep 2023

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Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Jäger MC, Joos FL, Winter DV, Odermatt A

Current Research in Toxicology,  14 Aug 2023

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Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation

Kędzierski J , Allard JA, Odermatt A, Smieško M

Toxicology Letters,  1 Aug 2023

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Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids

Jäger MC, Patt M, González-Ruiz V, Boccard J, Wey T, Winter DV, Rudaz S, Odermatt A

Molecular and Cellular Endocrinology,  15 Jun 2023

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Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population

Ben Rhouma B, Kley M, Kallabi F, Kacem FH, Kammoun T, Safi W, Keskes L, Mnif M, Odermatt A, Belguith N

Journal of Steroid Biochemistry and Molecular Biology,  31 Mar 2023

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Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters

Inderbinen SG, Kley M, Zogg M, Sellner M, Fischer A, Kędzierski J, Boudon S, Jetten AM, Smieško M, Odermatt A

Toxicology,  23 Mar 2022

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Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: the glycyrrhetinic acid-like factor (GALF) hypothesis

Morris DJ, Brem AS, Odermatt A

Journal of Steroid Biochemistry and Molecular Biology,  30 Nov 2021

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Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess

Beck KR, Odermatt A

Molecular and Cellular Endocrinology,  15 Mar 2021

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Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole

Inderbinen SG, Zogg M, Kley M, Smieško M, Odermatt A

Toxicology and Applied Pharmacology,  1 Feb 2021