22 Jan 2014 - 22 Jan 2014

Continuing Education - Neurotoxicology 2014: Current status and perspectives in developmental and neurotoxicological testing strategies, Zürich (CH)

The currently used regulatory test methods in the fields of neurotoxicity (NT) and developmental neurotoxicity (DNT) are mainly based on in vivo approaches using rodents. New developments, in particular the Adverse Outcome Pathway (AOP) framework aim at incorporating mechanistic informations into the risk assessment process, moving from solely apical animal testing to mechanism-based decision-making. In addition, the need of testing a large amount of chemicals as stated in the European REACH legislation, as well as the 3 R’s strategy for replacing, reducing and refining animal testing, have stimulated the development of alternative methods. Moreover, recent developments using cells of human origin derived from embryonic stem cells or induced pluripotent stem cells will allow safety testing based on human biology. Discussions and collaborations between scientists of academia and industry and scientists involved in risk assessment are necessary to define the requirements for the development of in vitro NT / DNT testing strategies suitable for regulatory purposes. Within the framework of the initiation of this dialogue between scientists and regulators, XeRR is organizing this symposium presenting some of these alternative methods for NT and DNT testing.

Organizer

XeRR and SCAHT

Location

University of Zürich Irchel

Link to Event

http://www.xerr.uzh.ch/research/weiterbildung-1/neurotox2014_en.html#17