EUSAAT 2018, 23 - 26 September 2018, Linz (A) - Abstract submission deadline: 31 May 2018
CEFIC-LRI Award 2018 - Improved alignment of the AOP concept in toxicology with the needs of risk assessment
The European Chemical Industry Council(Cefic), in conjunction with the Society of Environmental Toxicology and Chemistry (SETAC), the Association of European Toxicologists and European Societies of Toxicology (EUROTOX), and the International Society of Exposure Sciences (ISES), is offering a €100.000 award to support promising new research in the field of mammalian and environmental toxicology, with a specific focus on the improved alignment of the Adverse Outcome Pathway (AOP) concept in toxicology with the needs of risk assessment. See further information.
OECD launches QSAR Toolbox version 4.2
5 February 2018 - OECD launches QSAR Toolbox version 4.2. The Toolbox is a software application intended to the use of governments, chemical industry and other stakeholders in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals. For further information see this OECD website.
Bisphenol A: EU reduces limits for food contact materials
The EU Commission has published a new Regulation, to apply from 6 September 2018, that lowers the regulatory specific migration limit ('SML') for BPA in food contact materials from 0.6 to 0.05 mg/kg food and extends it to coating materials which are used to line food and drink cans. See also Q&A of the European Commission regarding Bisphenol A.
Draft guidance document for endocrine disruptors available for comments until 31 January 2018
The European Food Safety Authority (EFSA) and the European Chemicals Agency (ECHA) are inviting interested parties to comment on the draft guidance document for identifying endocrine disruptors under EU legislation for pesticides and biocides.
This draft guidance, which was requested by the European Commission, has been developed by the two agencies with the support of the Commission’s Joint Research Centre (JRC). In 2017 EFSA and ECHA conducted two targeted consultations on initial versions of the draft guidance with experts representing Member States and with stakeholders from industry and NGOs. SCAHT Director Martin Wilks contributed to this exercise on behalf of the European Association of Poison Centres and Clinical Toxicologists (EAPCCT). Following discussions with the European Commission, EFSA and ECHA are now inviting all interested parties to comment on the updated draft text by using the dedicated web form (links to EFSA and ECHA). The deadline for providing comments is 31 January 2018.
Dear friends and supporters of the SCAHT,
Two events of significant importance for the SCAHT highlighted our year 2017. The first was the visit by the State Secretary for Education, Research and Innovation to the SCAHT, the second the admission of the Fachhochschule Nordwestschweiz as a new collaborator institution of the SCAHT. Both events underline the recognition of the SCAHT as a successful research infrastructure in Switzerland and provide additional motivation to our research, education and regulatory toxicology efforts.
As we reflect on another positive and exciting year for the SCAHT we would like to thank you and your colleagues for your encouragement and support throughout the year. We wish you and your families a relaxing and peaceful festive season, and a very happy New Year 2018.
Martin Wilks and the SCAHT team
P. S. Please note that the SCAHT office will be closed from 23rd December 2017 until 2nd January 2018.
FHNW joins the SCAHT network as collaborator
SCAHT is dependent on the support of its partners, the universities of Basel, Geneva and Lausanne, who are represented in the highest decision making body, the SCAHT Foundation Council. As befits a network of research institutions, others may wish to join and for this a process of admission has been established. The School of Life Sciences of the Fachhochschule Nordwestschweiz (FHNW) already has collaborations with the SCAHT through the Molecular Toxicology group headed by Prof Laura Suter-Dick, and has expressed an interest to join the SCAHT network. The application was reviewed by the SCAHT Management Board and approved by the Foundation Council at its meeting in November, and the School has now been granted collaborator status, initially for a period of two years. At the end of this period, the Council will review the collaboration and take a final decision with regard to a future status as collaborator or partner.
EFSA BPA protocol endorsed
In December 2017, EFSA’s expert Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) discussed and endorsed a scientific protocol for the upcoming re-evaluation of Bisphenol A (BPA) hazards. The protocol is a detailed plan that defines upfront the scope, methodology and information needs before the assessment starts in 2018. The protocol was developed for the CEF Panel by an EFSA international working group including experts from Denmark, France, Germany, the Netherlands, Norway, Sweden and Switzerland, represented by Rex FitzGerald from the SCAHT. See further information.
Visit by the State Secretary to the SCAHT
On 29th November, the State Secretary for Education, Research and Innovation, Dr Mauro Dell’Ambrogio, together with the Head of the Research Unit, Dr Nicole Schaad, and Scientific Adviser Dr Cyrille Girardin, visited the SCAHT at the University of Geneva. The visit was hosted by the School of Pharmaceutical Sciences Geneva-Lausanne and took place in the recently opened Analytical Sciences laboratories at the Centre Médicale Universitaire which is home to a number of SCAHT-supported research groups.
The guests were welcomed by the university’s Vice-rector for research and SCAHT co-founder, Prof Denis Hochstrasser, together with the Deans of the Faculties for Medicine and Sciences, Profs Henri Bounameaux and Jérome Lacour, the President of the School of Pharmaceutical Sciences, Prof Jean-Luc Wolfender and SCAHT director Prof Martin Wilks. Participants included Geneva-based SCAHT research group leaders, as well as representatives of the SCAHT Management Board from the University of Basel and the Federal Office of Public Health. The interactive programme featured overview presentations of SCAHT research, educational and regulatory toxicology activities. A highlight of the visit was a tour of some of the state-of-the-art laboratory facilities to which the SCAHT has access through its collaboration with the university. This was exemplified using the contribution of proteomics and metabolomics to specific research questions which was presented by post-doctoral researchers funded by the SCAHT. The visit was rounded up by intensive discussions of the challenges that the federal offices face in human health risk assessment and management of chemicals, pharmaceuticals and pesticides, and how the SCAHT can help address these today and in the future. The guests appreciated the insight into how the SCAHT network operates, and especially the collaborative and translational nature of the SCAHT projects, bringing together researchers from different universities and disciplines, regulatory toxicologists and scientists from federal offices.
Feature update of the Effectopedia
The Effectopedia tool which is an integrative part of the AOP Knowledge Base allows quantitative depiction of the relationships between molecular initiating events, key events, and the in vivo adverse outcomes within an Adverse Outcome Pathway (AOP). In June 2017, Effectopedia was updated to include data templates allowing the use of time-dose responses as well as an aggregation function (additive, synergistic, antagonistic) for key events with more than one input. In December a further update is released with, among other features, a new user-friendly interface which also integrates the quantitative modelling tool (see OECD newsletter).