Feature update of the Effectopedia

The Effectopedia tool which is an integrative part of the AOP Knowledge Base allows quantitative depiction of the relationships between molecular initiating events, key events, and the in vivo adverse outcomes within an Adverse Outcome Pathway (AOP). In June 2017, Effectopedia was updated to include data templates allowing the use of time-dose responses as well as an aggregation function (additive, synergistic, antagonistic) for key events with more than one input. In December a further update is released with, among other features, a new user-friendly interface which also integrates the quantitative modelling tool (see OECD newsletter).

“Bridging the gap between academic researchers and regulators is the ongoing theme for the decade”

The Swiss Centre for Applied Human Toxicology (SCAHT) will have a major presence at OpenTox EURO 2017 in Basel November 21 - 23. SCAHT Director Martin Wilks will chair Session 1: Defined Approaches towards Regulatory Acceptance, and SCAHT Regulatory Toxicologist Rex FitzGerald will join him on the panel to present Test Guidelines, AOPs and IATA - current and future.

Rex FitzGerald says “Bridging the gap between academic researchers and regulators is the ongoing theme for the decade. OpenTox EURO is the place to see what regulators need as well as what scientists are doing. It is a great opportunity to define regulatory acceptance of different kinds of data.” Read more.

2-day SCAHT Research Retreat was well received

On August 28th and 29th the annual SCAHT Research Meeting was held in Montezillon (Neuchâtel). The event gathered researchers from all institutions participating in the SCAHT, as well as representatives from the Swiss regulatory authorities, for scientific discussions on the status and development of the research activities within the SCAHT. Professor Nicole Probst-Hensch from SwissTPH in Basel was the guest speaker and provided insights for SCAHT researchers on the use of epidemiological data in toxicology research. The event also provided a forum for in depth discussions on ongoing activities within the Core Projects, strengthening the SCAHT collaborative network.

20th International Congress on In Vitro Toxicology 2018, Berlin (D)

The aim of the conference which will take place on 15 - 18 October in Berlin (D) is to provide an opportunity to update attendees with the latest advances in the field of in vitro toxicology as well as facilitating networking with other delegates working in this area. Abstract submission will be opened in January 2018. For further information see conference website.

Cefic-LRI research grants - Submission deadline is 31 August 2017

The Long-range Research Initiative (LRI) programme of the European Chemical Industry Council (Cefic) is accepting research grant applications in areas including Toxicokinetics mammalian modelling (ECO44), Assessment of inhalation and dermal exposure in industrial/professional use (B20), Development of omics data analysis (C4), Understanding normal adaptation vs pathology and gene expression time dependence (C5), and Omics read-across (C6). Submission deadline is 31 August 2017. For further information see here.

Filling gaps in (eco)toxicity data by OECD QSAR toolbox

This toolbox is a software application intended for use by regulatory authorities, chemical industry and other stakeholders in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals. Version 4.0 was released in June 2017. New features:

  •  Automated and standardised workflows for skin sensitisation and short-term toxicity to fish,
  • Improved customisable reports,
  • Modernised and renewed IT system,
  • Expansion of databases and the introduction of the reliability score for alerts and databases,
  • Enhanced ADME (kinetics) information and improved presentation.

AOP online course now openly available

The Human Toxicology Project Consortium has developed an eLearning course on the AOP framework, its history and importance, and how to develop and submit quality AOPs to the AOP-Wiki. The course is openly available on this website. Other current AOP training activities are listed here.

Apply now for EFSA’s scientific panels

The European Food Safety Authority EFSA is looking for scientific experts for its ten Scientific Panels and its Scientific Committee, which are at the heart of EFSA’s mission to produce high-quality independent scientific advice for political decision-makers in Europe. Submit your application between 1 June and 8 September 2017. For further information click here.

ECHA releases key information on 15’000 chemicals

The European Chemicals Agency is making selected data on 15’000 chemicals available for download with the aim of increasing its use by researchers, regulatory authorities and businesses. The aim is to improve the safe use of chemicals, enable innovation and help avoid the unnecessary testing of chemicals on animals. Further information can be found on the ECHA website.

EFSA prototype Adverse Outcome Pathways (AOPs) for Parkinson’s disease and infant leukaemia related to pesticide exposure

The European Food Safety Authority (EFSA) Panel on Plant Protection Products and their Residues (PPR) were requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson’s disease and childhood leukaemia. The Panel proposes the use of the Adverse Outcome Pathway (AOP) conceptual framework, to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP-derived Integrated Approach for Testing and Assessment (IATA). See press release and publication.