Publications by group

Toxicity of metamizole on differentiating HL60 cells and human neutrophil granulocytes [Epub ahead of print]

Rudin D
Duthaler U
Toxicology
26/07/2019

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts

Zhou X
Luethi D
Sanvee GM
International Journal of Molecular Sciences
28/03/2019

PGC-1β modulates statin-associated myotoxicity in mice

Singh F
Zoll J
Duthaler U
Charles AL
Laverny G
McWilliams TG
Metzger D
Geny B
Archives of Toxicology
28/02/2019

Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle [Epub ahead of print]

Biochemical Pharmacology
20/02/2019

Non-immunological toxicological mechanisms of metamizole-associated neutropenia in [Epub ahead of print]

Rudin D
Lanzilotto A
Bachmann F
Housecroft CE
Constable EC
Drewe J
Haschke M
Biochemical Pharmacology
14/01/2019

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice

Paech F
Abegg VF
Duthaler U
Toxicology
01/11/2018

Effect of the catechol-O-methyltransferase inhibitors tolcapone and entacapone on fatty acid metabolism in HepaRG cells

Felser A
Duthaler U
Toxicological Sciences
01/08/2018

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Berger B
Bachmann F
Duthaler U
Haschke M
Frontiers in Pharmacology
24/07/2018

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Frontiers in Pharmacology
23/04/2018

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

Mingard C
Paech F
Journal of Applied Toxicology
31/03/2018

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

Paech F
Mingard C
Abegg VF
Toxicology
15/02/2018

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Paech F
Messner S
Spickermann J
Wind M
Schmitt-Hoffmann AH
Witschi AT
Howell BA
Church RJ
Woodhead J
Engelhardt M
Maurer M
Archives of Toxicology
30/11/2017

The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

Toxicology in Vitro
31/08/2017

Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones

Toxicology
15/07/2017

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

Prestigiacomo V
Weston A
Messner S
Lampart F
PLoS One
30/06/2017

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Frontiers in Pharmacology
14/06/2017

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

Archives of Toxicology
31/05/2017

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler P
Joerin L
Toxicological Sciences
01/05/2017

Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin

Brecht K
Riebel V
Couttet P
Paech F
Wolf A
Chibout SD
Pognan F
Uteng M
Toxicology in Vitro
30/04/2017

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

Haegler P
Grünig D
Berger B
PLoS One
30/01/2017

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

Berger B
Donzelli M
Maseneni S
Boess F
Roth A
Haschke M
Frontiers in Pharmacology
21/11/2016

Interactions between silica nanoparticles and phospholipid membranes

Kettiger H
Québatte G
Perrone B
Biochimica et Biophysica acta
30/09/2016

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency

Haegler P
Singh F
Joerin L
Felser A
Duthaler U
Frontiers in Physiology
10/08/2016

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

Witzigmann D
Quagliata L
Schenk SH
Quintavalle C
Hepatology Research
30/06/2016

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Bonifacio A
Mullen PJ
Mityko IS
Navegantes LC
Archives of Toxicology
31/01/2016

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Singh F
Charles AL
Schlagowski AI
Bonifacio A
Echaniz-Laguna A
Geny B
Zoll J
Antioxidants & Redox Signaling
10/01/2016

Comparative safety evaluation of silica-based particles

Kettiger H
Sen Karaman D
Schiesser L
Rosenholm JM
Toxicology In Vitro
25/12/2015

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Marti P
Stein C
Blumer T
Abraham Y
Dill MT
Pikiolek M
Orsini V
Jurisic G
Megel P
Makowska Z
Agarinis C
Tornillo L
Bouwmeester T
Ruffner H
Bauer A
Parker CN
Schmelzle T
Heim MH
Tchorz JS
Hepatology
30/11/2015

Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity

Haegler P
Berger B
Toxicology
02/10/2015

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

Bonifacio A
Sanvee GM
Biochimica et Biophysica Acta
31/08/2015

Pages