Publications by group

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice

Paech F
Abegg VF
Duthaler U

Effect of the catechol-O-methyltransferase inhibitors tolcapone and entacapone on fatty acid metabolism in HepaRG cells

Felser A
Duthaler U
Toxicological Sciences

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Berger B
Bachmann F
Duthaler U
Haschke M
Frontiers in Pharmacology

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Frontiers in Pharmacology

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

Mingard C
Paech F
Journal of Applied Toxicology

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

Paech F
Mingard C
Abegg VF

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Paech F
Messner S
Spickermann J
Wind M
Schmitt-Hoffmann AH
Witschi AT
Howell BA
Church RJ
Woodhead J
Engelhardt M
Maurer M
Archives of Toxicology

The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

Toxicology in Vitro

Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones


Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

Prestigiacomo V
Weston A
Messner S
Lampart F
PLoS One

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Frontiers in Pharmacology

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

Archives of Toxicology

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler P
Joerin L
Toxicological Sciences

Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin

Brecht K
Riebel V
Couttet P
Paech F
Wolf A
Chibout SD
Pognan F
Uteng M
Toxicology in Vitro

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

Haegler P
Grünig D
Berger B
PLoS One

Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail

Berger B
Donzelli M
Maseneni S
Boess F
Roth A
Haschke M
Frontiers in Pharmacology

Interactions between silica nanoparticles and phospholipid membranes

Kettiger H
Québatte G
Perrone B
Biochimica et Biophysica acta

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency

Haegler P
Singh F
Joerin L
Felser A
Duthaler U
Frontiers in Physiology

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

Witzigmann D
Quagliata L
Schenk SH
Quintavalle C
Hepatology Research

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Bonifacio A
Mullen PJ
Mityko IS
Navegantes LC
Archives of Toxicology

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Singh F
Charles AL
Schlagowski AI
Bonifacio A
Echaniz-Laguna A
Geny B
Zoll J
Antioxidants & Redox Signaling

Comparative safety evaluation of silica-based particles

Kettiger H
Sen Karaman D
Schiesser L
Rosenholm JM
Toxicology In Vitro

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Marti P
Stein C
Blumer T
Abraham Y
Dill MT
Pikiolek M
Orsini V
Jurisic G
Megel P
Makowska Z
Agarinis C
Tornillo L
Bouwmeester T
Ruffner H
Bauer A
Parker CN
Schmelzle T
Heim MH
Tchorz JS

Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity

Haegler P
Berger B

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

Bonifacio A
Sanvee GM
Biochimica et Biophysica Acta

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

Singh F
Charles AL
Schlagowski AI
Bonifacio A
Piquard F
Geny B
Zoll J
Biochimica et Biophysica acta

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor

Seeland S
Kettiger H
Murphy M
Treiber A
Giller J
Kiss A
Sube R
Hafner M
Pharmacology Research & Perspectives

Scientific Basis for Regulatory Decision-Making of Nanomaterials. Report on the Workshop, 20 – 21 January 2014, Center of Applied Ecotoxicology, Dübendorf

Studer C
Gasic B
von Goetz N
Hoet P
Kägi R
Kase R
Kobe A
Nowack B
Rothen-Rutishauser B
Schirmer K
Schneider G
Vermeissen E
Wick P
Walser T

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

Zhang L
Tang F
Hynx D
Kohler R
Bichet S
Hess D
Cron P
Hemmings BA
Hergovich A
Schmitz-Rohmer D
Current Biology

Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells

Chantong B
Lister A
Journal of Neuroinflammation