Publications 2017

Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies

Mamoulakis C
Tsarouhas K
Fragkiadoulaki I
Heretis I
Spandidos DA
Tsitsimpikou C
Tsatsakis A
Pharmacology & Therapeutics

Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study

Randazzo GM
Tonoli D
Strajhar P
Xenarios I
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

ART, Stoffenmanager, and TRA: A Systematic Comparison of Exposure Estimates Using the TREXMO Translation System

Gasic B
Annals of Work Exposures and Health

Unravelling the effects of multiple experimental factors in metabolomics, analysis of human neural cells with hydrophilic interaction liquid chromatography hyphenated to high resolution mass spectrometry

Journal of Chromatography. A.

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

Paech F
Messner S
Spickermann J
Wind M
Schmitt-Hoffmann AH
Witschi AT
Howell BA
Church RJ
Woodhead J
Engelhardt M
Maurer M
Archives of Toxicology

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity

Kiene K
Schenk SH
Porta F
Ernst A
Witzigmann D
Grossen P
European Journal of Pharmaceutics and Biopharmaceutics

Comparing the Advanced REACH Tool's (ART) Estimates With Switzerland's Occupational Exposure Data

Gasic B
Schinkel J
Annals of Work Exposures and Health

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases

Engeli RT
Rohrer SR
Vuorinen A
Herdlinger S
Kaserer T
Leugger S
International Journal of Molecular Sciences

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases

Romand S
Spaggiari D
Marsousi N
Samer C
Desmeules J
Daali Y
Journal of Pharmaceutical and Biomedical Analysis

Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects

Dolder PC
Strajhar P
Vizeli P
Hammann F
Frontiers in Pharmacology

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells

Siegrist S
Kettiger H
Fasler-Kan E
Toxicology In Vitro

The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

Grünig D
Felser A
Toxicology in Vitro

Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse

Miró Ò
Galicia M
Dargan P
Dines AM
Giraudon I
Heyerdahl F
Hovda KE
Yates C
Wood DM
Euro-DEN Research Group
Toxicology Letters

Virtual screening applications in short-chain dehydrogenase/reductase research

Beck KR
Kaserer T
The Journal of Steroid Biochemistry and Molecular Biology

Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones


Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

Prestigiacomo V
Weston A
Messner S
Lampart F
PLoS One

Development of a New Extraction Device Based on Parallel-Electromembrane Extraction

Drouin N
Mandscheff JF
Schappler J
Analytical Chemistry

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Frontiers in Pharmacology

Stoffenmanager(R) Algorithm Within Version 6 Differs from the Published Algorithm Within Old Versions and TREXMO

Gasic B
Annals of Work Exposures and Health

Potential mechanisms of development-dependent adverse effects of the herbicide paraquat in 3D rat brain cell cultures

Broyer A
Zoia D
Schilt C
Greggio C
Fournier M
Monnet-Tschudi F

IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes

Archives of Toxicology

High-resolution mass spectrometry as an alternative detection method to tandem mass spectrometry for the analysis of endogenous steroids in serum

Ponzetto F
Baume N
Kuuranne T
Saugy M
Nicoli R
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler P
Joerin L
Toxicological Sciences

OECD/EFSA Workshop on Developmental Neurotoxicity (DNT): The Use of Non-Animal Test Methods for Regulatory Purposes

Fritsche E
Crofton KM
Hernandez AF
Hougaard Bennekou S
Bal-Price A
Reaves E
Terron A
Solecki R
Gourmelon A

Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin

Brecht K
Riebel V
Couttet P
Paech F
Wolf A
Chibout SD
Pognan F
Uteng M
Toxicology in Vitro

Characterisation of extracellular vesicle-subsets derived from brain endothelial cells and analysis of their protein cargo modulation after TNF exposure

Journal of Extracellular Vesicles

Systems Toxicology: Real World Applications and Opportunities

Hartung T
Jennings P
Mirams GR
Peitsch MC
Rostami-Hodjegan A
Shah I
Sturla SJ
Chemical Research in Toxicology

Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole

Beck KR
Bächler M
Vuorinen A
Wagner S
Akram M
Griesser U
Temml V
Klusonova P
Yamaguchi H
Biochemical Pharmacology

Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids

Strajhar P
Tonoli D
Jeanneret F
Imhof RM
Malagnino V

Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing

Eggermann E
Charvet I
Toni N
Greggio C
Broyer A
Monnet-Tschudi F
Toxicology In Vitro