Publications 2018

Longitudinal investigation of the metabolome of 3D aggregating brain cell cultures at different maturation stages by 1H HR-MAS NMR

Diserens G
Vermathen M
Vermathen P
Analytical and Bioanalytical Chemistry
31/10/2018

Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites

Marsousi N
Daali Y
Fontana P
Reny JL
Ancrenaz-Sirot V
Calmy A
Desmeules JA
Clinical Pharmacokinetics
31/10/2018

Preclinical hazard evaluation strategy for nanomedicines [Epub ahead of print]

Siegrist S
Cörek E
Detampel P
Wick P
Nanotoxicology
05/09/2018

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation [Epub ahead of print]

Mech A
Rasmussen K
Jantunen P
Alessandrelli M
Bernauer U
Bleeker EAJ
Bouillard J
Di Prospero Fanghella P
Draisci R
Dusinska M
Encheva G
Flament G
Haase A
Handzhiyski Y
Herzberg F
Jacobsen NR
Jeliazkov V
Jeliazkova N
Nymark P
Grafström R
Oomen AG
Polci ML
Riebeling C
Shivachev B
Stateva S
Tanasescu S
Tsekovska R
Wallin H
Zellmer S
Apostolova MD
Nanotoxicology
05/09/2018

Effect of the catechol-O-methyltransferase inhibitors tolcapone and entacapone on fatty acid metabolism in HepaRG cells

Felser A
Duthaler U
Toxicological Sciences
01/08/2018

A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models [Epub ahead of print]

Sanvido O
Schmid K
Bormann P
Regulatory Toxicology and Pharmacology
29/07/2018

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Berger B
Bachmann F
Duthaler U
Haschke M
Frontiers in Pharmacology
24/07/2018

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice [Epub ahead of print]

Paech F
Abegg VF
Duthaler U
Toxicology
18/07/2018

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Bal-Price A
Hogberg HT
Crofton KM
Daneshian M
Fritsche E
Heinonen T
Hougaard Bennekou S
Klima S
Piersma AH
Sachana M
Shafer TJ
Terron A
Monnet-Tschudi F
Viviani B
Waldmann T
Westerink RHS
Witters H
Zurich MG
Leist M
ALTEX
09/07/2018

Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways

Villeneuve DL
Landesmann B
Allavena P
Ashley N
Bal-Price A
Corsini E
Halappanavar S
Hussell T
Laskin D
Lawrence T
Nikolic-Paterson D
Pallardy M
Paini A
Pieters R
Roth R
Tschudi-Monnet F
Toxicological Sciences
01/06/2018

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells

Frontiers in Pharmacology
23/04/2018

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

Mingard C
Paech F
Journal of Applied Toxicology
31/03/2018

Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss men [Epub ahead of print]

Clinical Biochemistry
16/03/2018

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Engeli RT
Fürstenberger C
Heliyon
28/02/2018

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

Paech F
Mingard C
Abegg VF
Toxicology
15/02/2018

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes [Epub ahead of print]

Fritsche E
Grandjean P
Crofton KM
Aschner M
Goldberg A
Heinonen T
Hessel EVS
Hogberg HT
Bennekou SH
Lein PJ
Leist M
Mundy WR
Paparella M
Piersma AH
Sachana M
Schmuck G
Solecki R
Terron A
Monnet-Tschudi F
Witters H
Bal-Price A
Toxicology and Applied Pharmacology
12/02/2018

Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software

Marsousi N
Desmeules JA
Daali Y
Biopharmaceutics & Drug Disposition
31/01/2018

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Terron A
Bal-Price A
Paini A
Monnet-Tschudi F
Bennekou SH
EFSA WG EPI1 Members
Leist M
Schildknecht S
Archives of Toxicology
31/01/2018

Navigating in vitro bioactivity data: investigating available resources using model compounds

Ilmjarv S
Augsburger F
Tjalling Bolleman J
Liechti R
Bridge A
Jaquet V
Xenarios I
Krause KH
bioRxiv
17/01/2018