ONTOX

The ONTOX Project is a collaborative Horizon Europe research initiative aiming at transforming chemical safety assessment by building an ontology-based framework rooted in human data, innovative methods (NAMs), adverse outcome pathways and probabilistic risk assessment. The project seeks to improve how chemical risks are identified and characterised, address emerging health concerns, and provide tools and strategies that enhance regulatory decision-making across jurisdictions.

By fostering international cooperation among academic institutions, regulatory agencies, and industry partners, ONTOX strives to accelerate the regulatory uptake of innovative methods, promotes data interoperability, and aligns with global needs for safer and more sustainable chemical management.

Prof. Dr. med. Ellen Fritsche contributes to the ONTOX project as a scientific partner and work package lead for WP9 (Developmental Neurotoxicity), supporting the development and regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery (IVB).

ONTOX is part of the ASPIS cluster promoting the ASPA workflow for perfoming next generation risk assessement.